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Liquid Levodopa/Carbidopa Produces Significant Improvement in Motor Function without Dyskinesia Exacerbation Neurol 47:1493-1495, Pappert,E.J.,et al, 1996 See this aricle in Pubmed Article Abstract We performed the first double-blind crossover comparison between levodopa/ carbidopa(LD/CD)in optimized liquid versus tablet doses to measure plasma LD levels and relative effects on disabilities(motor function,fluctuations and dyskinesias)in patients with Parkinson's disease.Twenty-three subjects with motor fluctuations were optimized with open-label LD-CD tablets and liquid.In a double-dummy design,patients randomly received 2 weeks of liquid and 2 weeks of tablet Ld/CD.Twice during each arm,we evaluated patients hourly 9 a.m.to 4 p.m.with the use of plasma LD levels,the Unified Parkinson's Disease Rating Scale,a dyskinesia rating scale and"on- off"ratings.Patients receiving liquid CD/LD ingested significantly higher doses and had significantly improved motor function and total"on"time without an increase in dyskinesia severity.The number of motor fluctuations in the two phases was not significantly different.LD levels and variability were also equivalent with the two formulations.At optimized dosing,liquid CD/LD offers a means to significantly improve motor disability in patients with Parkinson's disease without exacerbating dyskinesia.

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(click to filter results - removes previous filter) L-dopa L-dopa,liquid Parkinson disease Parkinson disease,fluctuations in Parkinson disease,treatment of treatment of neurologic disorder

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